Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia
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چکیده
منابع مشابه
Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.
All characterized mammalian aquaporins (AQPs) are localized to plasma membranes where they function chiefly to mediate water transport across cells. Here we show that AQP6 is localized exclusively in intracellular membranes in renal epithelia. By using a polyclonal antibody to the C terminus of AQP6, immunoblots revealed a major 30-kDa band in membranes from rat renal cortex and medulla. Endogl...
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The aquaporins (AQPs) are a family of membrane water channel proteins, and they play a central role in water homeostasis. The seven isoforms, namely AQP1, AQP2, AQP3, AQP4, AQP6, AQP7 and AQP11, are expressed in the kidney [1]. Many studies have been carried out in animal models to prove the relationship between various pathologic renal conditions and AQPs. For instance, a decrease in the expre...
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Aquaporin-1 (AQP1) is a membrane channel that allows rapid water movement driven by a transmembrane osmotic gradient. It was claimed to have a secondary function as a cyclic nucleotide-gated ion channel. However, upon reconstitution into planar bilayers, the ion channel exhibited a 10-fold lower single channel conductance than in Xenopus oocytes and a 100-fold lower open probability (<10(-6)) o...
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Aquaporin (AQP) 6 belongs to the aquaporin water channel family. Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have shown AQP6 to flicker rapidly between closed and open status. The atomic structure of AQP1 and amino acid sequence alignments of the mammalian aquaporins reveal two well conserved glycine residues: Gly-57 ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.10.5808